Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project الاستجابة الحادة لالتهاب الجيوب الأنفية لتلوث الهواء يعتمد على خصائص حبيبات الغبار وحالتها التأكسدية. مشروع RAPTES |
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Subject |
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Enviromental sciences |
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Document Language |
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English |
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Abstract |
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Objectives To investigate which air pollution
characteristics are associated with biomarkers for acute
nasal airway inflammation in healthy subjects. We
hypothesised that associations would be strongest for
oxidative potential (OP) of particles.
Methods 31 volunteers were exposed to ambient air
pollution at five sites in The Netherlands: two traffic
sites, an underground train station, a farm and an urban
background site. Each subject visited at least three sites
between March and October 2009 and was exposed for
5 h per visit including exercise for 20 min every hour (h).
Air pollution measurements during this 5-h-period
included particulate matter (PM) mass concentration,
elemental composition, elemental and organic carbon
(OC), particle number concentration, OP, endotoxins,
O3 and NO2. Pro-inflammatory biomarkers were
measured before, 2 and 18 h postexposure, including
cytokine IL-6 and IL-8, protein and lactoferrin in nasal
lavage (NAL) as well as IL-6 in blood. One- and twopollutant
mixed models were used to analyse associations
between exposure and changes in biomarkers.
Results In two-pollutant models, cytokines in NAL were
positively associated with OC, endotoxin and NO2;
protein was associated with NO2; and lactoferrin was
associated with all PM characteristics that were high at
the underground site. In blood, associations with OC and
endotoxin were negative.
Conclusions We observed no consistent effects in twopollutant
models for PM mass concentration and OP.
Instead, we found consistent associations with nasal
inflammatory markers for other PM characteristics,
specifically OC, endotoxin and NO2. |
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ISSN |
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1351-0711 |
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Journal Name |
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OCCUPATIONAL AND ENVIRONMENTAL MEDICINE |
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Volume |
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70 |
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Issue Number |
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5 |
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Publishing Year |
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1434 AH
2013 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, June 4, 2013 |
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Researchers
| Maaike Steenhof | Steenhof, Maaike | Researcher | | |
| Ian S. Mudway | Mudway, Ian S. | Researcher | | |
| Ilse Gosens | Gosens, Ilse | Researcher | | |
| Gerard Hoek | Hoek, Gerard | Researcher | | |
| Krystal J Godri | Godri, Krystal J | Researcher | | |
| Frank J Kelly | Kelly, Frank J | Researcher | | |
| Roy M Harrison | Harrison, Roy M | Researcher | | |
| Raymond H. H Pieters | Pieters, Raymond H. H | Researcher | | |
| Flemming R Cassee | Cassee, Flemming R | Researcher | | |
| Erik Lebret | Lebret, Erik | Researcher | | |
| Bert A Brunekreef | Brunekreef, Bert A | Researcher | | b.brunekreef@uu.nl |
| Maciej Strak | Strak, Maciej | Researcher | | |
| Nicole A. H Janssen | Janssen, Nicole A. H | Researcher | | |
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Files
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35620.pdf
| pdf | Acute nasal pro-inflammatory response to air
pollution depends on characteristics other than
particle mass concentration or oxidative potential:
the RAPTES project |
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