تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
تركيب حبيبات الغبار يؤثر على الالتهاب الشعبي ومؤشرات التزاحم. مشروع RAPTES
Composition of PM Affects Acute Vascular Inflammatory and Coagulative Markers - The RAPTES Project
 
الموضوع : علوم البيئة 
لغة الوثيقة : الانجليزية 
المستخلص : Background: Exposure to ambient particulate matter (PM) has been associated with adverse cardiovascular effects in epidemiological studies. Current knowledge of independent effects of individual PM characteristics remains limited. Methods: Using a semi-experimental design we investigated which PM characteristics were consistently associated with blood biomarkers believed to be predictive of the risk of cardiovascular events. We exposed healthy adult volunteers at 5 different locations chosen to provide PM exposure contrasts with reduced correlations among PM characteristics. Each of the 31 volunteers was exposed for 5 h, exercising intermittently, 3-7 times at different sites from March to October 2009. Extensive on-site exposure characterization included measurements of PM mass and number concentration, elemental-(EC) and organic carbon (OC), trace metals, sulfate, nitrate, and PM oxidative potential (OP). Before and 2 h and 18 h after exposure we measured acute vascular blood biomarkers - C-reactive protein, fibrinogen, platelet counts, von Willebrand Factor, and tissue plasminogen activator/plasminogen activator inhibitor-1 complex. We used two-pollutant models to assess which PM characteristics were most consistently associated with the measured biomarkers. Results and Conclusion: We found OC, nitrate and sulfate to be most consistently associated with different biomarkers of acute cardiovascular risk. Associations with PM mass concentrations and OP were less consistent, whereas other measured components of the air pollution mixture, including PNC, EC, trace metals and NO2, were not associated with the biomarkers after adjusting for other pollutants. 
ردمد : 1932-6203 
اسم الدورية : PLOS ONE 
المجلد : 8 
العدد : 3 
سنة النشر : 1434 هـ
2013 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Monday, June 3, 2013 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
Maciej StrakStrak, Maciej باحث  
Gerard HoekHoek, Gerard باحث  
Krystal J GodriGodri, Krystal J باحث  
Ilse GosensGosens, Ilse باحث  
Ian S. MudwayMudway, Ian S. باحث  
Rene van Oerlevan Oerle, Rene باحث  
Henri M. H SpronkSpronk, Henri M. H باحث  
Flemming R CasseeCassee, Flemming R باحث  
Erik LebretLebret, Erik باحث  
Frank J. KellyKelly, Frank J. باحث  
Roy M HarrisonHarrison, Roy M باحث  
Bert BrunekreefBrunekreef, Bert باحث  
Maaike SteenhofSteenhof, Maaike باحث  
Nicole A. H JanssenJanssen, Nicole A. H باحث nicole.janssen@rivm.nl

الملفات

اسم الملفالنوعالوصف
 35611.pdf pdfComposition of PM Affects Acute Vascular Inflammatory and Coagulative Markers - The RAPTES Project

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