Main Page
Deanship
The Dean
Dean's Word
Curriculum Vitae
Contact the Dean
Vision and Mission
Organizational Structure
Vice- Deanship
Vice- Dean
KAU Graduate Studies
Research Services & Courses
Research Services Unit
Important Research for Society
Deanship's Services
FAQs
Research
Staff Directory
Files
Favorite Websites
Deanship Access Map
Graduate Studies Awards
Deanship's Staff
Staff Directory
Files
Researches
Contact us
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Deanship of Graduate Studies
Document Details
Document Type
:
Thesis
Document Title
:
Evaluation of Urolithin, a Pomegranate Metabolite as an Inhibitor of Obesity Driven Endoplasmic Reticulum Stress and Inflammation
تقييم يوروليثين ( ايضة الرمان ) كمثبط لإجهاد الشبكة الاندوبلازمية والإلتهاب الناجم عن السمنة
Subject
:
Faculty of Science
Document Language
:
Arabic
Abstract
:
Obesity is a metabolic disease characterized by the accumulation of fat in the body. Surprisingly, the prevalence of obesity and its associated co-morbidities is on the increase and no known cure yet. The current pharmacologic interventions are associated with severe side effects and often not suitable for long term use. Therefore, this project aimed to access the potentials of urolithins, the gut microbiota metabolites of ellagitannins and ellagic acid on their ability to attenuate obesity and its associated inflammation and endoplasmic reticulum stress. Animals were divided into four groups with 6 rats per group. Control rats were maintained on a chow diet and the other three groups were fed on a high-fat diet until they develop obesity and thereafter treated with urolithin A and B. The animals fed on a high-fat diet gained more weight, developed hepatic ER stress, and hypothyroidism. However, treatment with urolithin A and B decreased body weight gain, reduced hepatic ER stress and restored triiodothyronine level. Urolithin A effect on inflammation is cytokine-dependent. Treatment with urolithin A and B showed hepatoprotective potentials through their ability to restore hepatic levels of AST and ALT. The results of this study showed the potential anti-obesity effect of urolithin A and B. These results revealed that these metabolites reduced body weight, protect against liver damage, and improved metabolic function. It also showed that both urolithin A and B have the potential to reduced hepatic ER stress.
Supervisor
:
Dr. Wesam H. Abdulaal
Thesis Type
:
Master Thesis
Publishing Year
:
1442 AH
2021 AD
Co-Supervisor
:
Dr. Mustafa Zeyadi
Added Date
:
Wednesday, June 23, 2021
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
زهير أحمد الشهري
Alshehri, Zuhair Ahmed
Researcher
Master
Files
File Name
Type
Description
47066.pdf
pdf
Back To Researches Page