Document Details

Document Type : Article In Journal 
Document Title :
The crossroads between cancer stem cells and aging
The crossroads between cancer stem cells and aging
 
Document Language : English 
Abstract : The cancer stem cell (CSC) hypothesis suggests that only a subpopulation of cells within a tumour is responsible for the initiation and progression of neoplasia. The original and best evidence for the existence of CSCs came from advances in the field of haematological malignancies. Thus far, putative CSCs have been isolated from various solid and non-solid tumours and shown to possess self-renewal, differentiation, and cancer regeneration properties. Although research in the field is progressing extremely fast, proof of concept for the CSC hypothesis is still lacking and key questions remain unanswered, e.g. the cell of origin for these cells. Nevertheless, it is undisputed that neoplastic transformation is associated with genetic and epigenetic alterations of normal cells, and a better understanding of these complex processes is of utmost importance for developing new anti-cancer therapies. In the present review, we discuss the CSC hypothesis with special emphasis on age-associated alterations that govern carcinogenesis, at least in some types of tumours. We present evidence from the scientific literature for age-related genetic and epigenetic alterations leading to cancer and discuss the main challenges in the field 
ISSN : 1471-2407 
Journal Name : BMC cancer 
Volume : 15 
Issue Number : 1 
Publishing Year : 1436 AH
2015 AD 
Article Type : Article 
Added Date : Thursday, April 28, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Sara Santos FrancoFranco, Sara SantosInvestigator  
Hadas Raveh-AmitRaveh-Amit, Hadas Researcher  
Julianna KobolákKobolák, Julianna Researcher  
Mohammed H. AlqahtaniAlqahtani, Mohammed H.Researcher  
Ali MobasheriMobasheri, Ali Researcher  
András DinnyesDinnyes, András Researcher andras.dinnyes@biotalentum.hu

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