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Faculty of Medicine
Document Details
Document Type
:
Article In Journal
Document Title
:
Histopathological Study of Three Leishmania Major Strains
Histopathological Study of Three Leishmania Major Strains
Subject
:
Clinical Parasitology
Document Language
:
English
Abstract
:
Amastigotes count in inoculated foot pad and histopathologicaJ study of infected mice were performed to study three Leishmania major strains: the Senegalese strain MHOM/SN/OOIDKI(SN), the Sudanese strain MHOMlSO/89/UG8(SO), and the Saudi strain MHOMlSAl84/JISH(SA). Eight-week-old male BALB/c mice were divided into three groups. Each group was infected with one of the studied strains. Amastigotes in the inoculated foot of infected. mice in the three groups were counted at 30 and 45 days using modified fluorescence diacetate/ethidium bromide viability test, The number of amastigotes in the SA group was found to be significantly lower than that of the other two groups at both durations. There was no significant difference between the number of amastigotes in the SN and SO strains at 30 days, but it was significantly higher in the SN group than that of the SD group at 45 days post-inoculation. In the animals studied, tissue samples were obtained from the skin, liver, spleen, and testes for gross pathological changes and histopathological evaluation. The SO strain started earlier and led a more aggressive course. The SN and SA strains were less aggressive. The SA strain showed changes at an earlier time and resulted in a more aggressive course of the disease. The SN and SA strains were less aggressive. The SA strain showed the most chronic course of the three
ISSN
:
1319-1004
Journal Name
:
Medical Science Journal
Volume
:
7
Issue Number
:
1
Publishing Year
:
1419 AH
1999 AD
Article Type
:
Article
Added Date
:
Thursday, April 19, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
عدنان أمين
Amin, Adnan
Investigator
Doctorate
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32915.pdf
pdf
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