Main Page
About
Faculty
Dean
Organizational Structure
Academic Accreditations
"Strategic Plan "Ebtesama-Smile
Administration
Vice Deanships
Academic Affairs
Female Section
Graduate Studies and Research
University Dental Hospital
Development
Departments
Diagnostic Oral Sciences
Periodontology
Oral Biology
Oral & Maxillofacial Prosthodontics
Oral & Maxillofacial Surgery
Endodontics
Restorative Dentistry
Orthodontics
Pediatric Dentistry
Dental Public Health
Goals and Objectives
Education
Bachelor
Interns Program
Postgraduate Studies
Research
University Dental Hospital
Community Services
House of Expertise
Files
Contact Us
Directory of Faculty Staff
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
Effect of Periodontal Disease Severity on Altered Neutrophil Response in Diabetic Patients
Effect of Periodontal Disease Severity on Altered Neutrophil Response in Diabetic Patients
Document Language
:
English
Abstract
:
Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to defective secretion or activity of insulin. Periodontitis presents a challenge in the control of DM, due to the infectious burden. Objective: The aim of the present study was to evaluate superoxide production and protein kinase C activity in neutrophils of diabetic patients with periodontal disease. Methods: Fifty diabetics were included and grouped into various degrees of periodontitis severity based on clinical and radiographic evaluation. Forty five healthy volunteers with no signs of periodontitis or diabetes were used as controls. Superoxide production and the localization of protein kinase C (PKC) were compared in resting and FMLP or PMA-stimulated neutrophils. Superoxide production was evaluated by reduction of cytochrome C, while PKC activity was measured by the phosphorylation of histone with radiolabeled ATP. Results: Both resting and FMLP or PMA stimulated neutrophils from diabetic patients with severe periodontitis produced significantly more superoxide than diabetics without periodontitis and diabetics with mild or moderate periodontitis (p
ISSN
:
0
Journal Name
:
JDR
Volume
:
1256
Issue Number
:
1
Publishing Year
:
2003 AH
2003 AD
Article Type
:
Article
Added Date
:
Tuesday, May 20, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ممدوح كريمة
Karima, Mamdouh
Investigator
Doctorate
mkarimah@kau.edu.sa
Files
File Name
Type
Description
Effect of Periodontal Disease Severity.pdf
pdf
Back To Researches Page